Pathogenesis of Ischaemicrt disease

Atherosclerosis is implicated in the pathway of Ischaemic heart       disease. It is a progressive inflammatory disease of the arterial wall that is characterized by focal lipid rich deposits of atheroma that remain clinically silent until they become large enough to impair arterial perfusion or until ulceration or disruption of the lesion results in thrombotic occlusion or embolisation of the affected vessels.

In an established atherosclerotic plaque, macrophages mediate inflammation and smooth muscle cell promote repair. If inflammation predominates, the plaques become active or unstable and may be complicated by ulceration and superadded thrombosis. Any branch in the integrity of the thrombosis that extends into the atheromatous plaque and the arterial lumen. This type of plaque event may cause arterial or complete obstruction at the site of lesion and distal embolisation resulting in infarction or ischemia of the affected organ.More details