Friday, November 2, 2012

Pharmacologic treatment of hypertensive patient


A large number of drugs are currently available for reducing BP. More than two-thirds of hypertensive individuals cannot be controlled on one drug and will require two or more anti hypertensive agents selected from different drug classes. Trials that have compared the major classes of anti-hypertensive drug (thaiazides, beta-blocker, calcium) have shown no consistent or important differences in outcome, efficacy, side-effects or quality of life.
The choice of anti hypertensive therapy is therefore usually dictated by cost, convenience, the response to treatment and freedom of side-effects.co-morbid conditions may have an important influence on initial drug selection.
  • ·   Thiazides and other diuretics
  • ·  Beta-adrenoreceptor antagonist: Metoprolol, atenolol, and bisoprolol are cardioselective.
  • · Labetolal and carvedilol:these are combined α and β adrenoreceptor
Since most hypertensive patients will require two or more antihypertensive medications to achieve their BP goals, addition of a second drug from a different class should be initiated when use of a single agent in adequate doses fails to achieve the goal.More Details



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